What medicine will make you tell the truth?

This refers to the expression "truth medicine " in the context of thiopental. This expression is sometimes used figuratively to describe how some people when under the influence of thiopental or similar drugs, can be more open or talkative than they would normally be. Thiopental and other barbiturates are sometimes referred to as "truth serum" or "truth drugs" because people may be more likely to express their thoughts and emotions more freely when under their influence.

The term "truth serum" has often been used in the context of drugs or medications that can alter a person's consciousness and presumably make them more open to receiving relevant information. The use of barbiturates, including thiopental, may be mentioned in the context of the use of these groups of drugs by intelligence and special services.

The term "thiopental disinhibition" may refer to the concept of using thiopental (pentothal) to facilitate general relaxation and tension relief, often in a psychotherapeutic context. Please note that thiopental is primarily intended for medical procedures, such as general anesthesia, and should be used only by qualified medical professionals.

History of appearance

Thiopental was first synthesized in 1936 by chemists Ernst Fraisel and Henning Schoenberg in Germany. This barbiturate was developed as a short-acting anesthetic for use in medical procedures. The name "pentothal" comes from the combination of the words "pentane" (a pentagonal hydrocarbon) and "sodium" (salt).

In the 1930s and 1940s, thiopental was introduced into medical practice as a general anesthetic agent, allowing for a quick and effective introduction of a patient into a state of general anesthesia. Its short duration of action made it a preferred means of inducing anesthesia before surgery.

Thiopental has also been used as a means to alleviate epileptic seizures and some other medical conditions. However, due to the development of safer anesthetic agents and the risks associated with the use of barbiturates, its use has been decreasing in favor of other drugs.

How does thiopental work?

Thiopental, also known as pentothal, belongs to the class of barbiturates, and its mechanism of action is related to its effect on gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system.

Mechanism of action of thiopental:

1. Increase in GABA activity: Thiopental increases GABA activity by binding to GABA-A (gamma-aminobutyric acid type A) receptors on the surface of neurons in the central nervous system.
2. Opening of ion channels: as a result of binding to receptors, thiopental enhances the effect of GABA on ion channels, which leads to their opening.
3. The opening of ion channels, mainly chloride channels, allows chloride to flow into the neuron.
4. Hyperpolarization of the membrane: as a result of the internal flow of chloride, the neuronal membrane is hyperpolarized. This means that the membrane potential becomes more negative.
5. Inhibition of neuronal excitability: hyperpolarization of the membrane leads to inhibition of neuronal excitability, which means that it becomes less prone to excitation.

Thiopental is a short-acting barbiturate that is widely used in medical practice to induce general anesthesia.

• Rapid onset of sleep
• Deep muscle relaxation
• Lowering of blood pressure
• Changes in mental state
• Minimal excitement
• Short time of action
• Depression of breathing
• Loss of consciousness

Thiopental should only be used under the supervision of experienced medical professionals in conditions that ensure the safety of the patient. Thiopental is a generic drug and can be manufactured by various pharmaceutical companies around the world. The drug may have different trade names in different countries, and manufacturers may vary from region to region. Self-use or illegal use of such drugs can have serious health risks.